The lung microbiome, peripheral gene expression, and recurrence-free survival after resection of stage II non-small cell lung cancer.

ABSTRACT:

Background

Cancer recurrence after tumor resection in early-stage non-small cell lung cancer (NSCLC) is common, yet difficult to predict. The lung microbiota and systemic immunity may be important modulators of risk for lung cancer recurrence, yet biomarkers from the lung microbiome and peripheral immune environment are understudied. Such markers may hold promise for prediction as well as improved etiologic understanding of lung cancer recurrence.

Methods

In tumor and distant normal lung samples from 46 stage II NSCLC patients with curative resection (39 tumor samples, 41 normal lung samples), we conducted 16S rRNA gene sequencing. We also measured peripheral blood immune gene expression with nanoString®. We examined associations of lung microbiota and peripheral gene expres

SUBMITTER: Peters BA 

PROVIDER: S-EPMC9609265 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature