Engineering the xylose metabolism in Schizochytrium sp. to improve the utilization of lignocellulose.

ABSTRACT:

Background

Schizochytrium sp. is a heterotrophic, oil-producing microorganism that can efficiently produce lipids. However, the industrial production of bulk chemicals using Schizochytrium sp. is still not economically viable due to high-cost culture medium. Replacing glucose with cheap and renewable lignocellulose is a highly promising approach to reduce production costs, but Schizochytrium sp. cannot efficiently metabolize xylose, a major pentose in lignocellulosic biomass.

Results

In order to improve the utilization of lignocellulose by Schizochytrium sp., we cloned and functionally characterized the genes encoding enzymes involved in the xylose metabolism. The results showed that the endogenous xylose reductase and xylulose kinase genes possess corresponding functional a

SUBMITTER: Wang LR 

PROVIDER: S-EPMC9609267 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature