The role of inflammatory miRNA-mRNA interactions in PBMCs of colorectal cancer and obesity patients.

ABSTRACT:

Introduction

Inflammation is a critical hallmark in obesity and colorectal cancer (CRC). This study aimed to investigate effective microRNA (miRNA)-messenger RNA (mRNA) interactions on inflammatory networks involved in obesity and CRC.

Methods

The literature searches were applied to identify genes expression reported on peripheral blood mononuclear cells (PBMCs) and/or blood of CRC subjects and to find inflammatory miRNA  in blood samples. Furthermore, bioinformatics analysis was utilized to find inflammatory miRNA:mRNA interactions of the genes. Finally, a case-control study was set to investigate the expression of LAMC1 and GNB3 genes besides miR-10b, miR-506-3p, miR-150-5p, and miR-124-3p in CRC and control subjects.

Results

The expression of LAMC1 gene in healthy

SUBMITTER: Gholami M 

PROVIDER: S-EPMC9609448 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature