Exposure Prioritization (Ex Priori): A Screening-Level High-Throughput Chemical Prioritization Tool.

ABSTRACT: To estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We designed Ex Priori, a flexible dashboard-type screening-level exposure model, to rapidly visualize exposure rankings from consumer product use. Ex Priori is Excel-based. Currently, it is parameterized for seven routes of exposure for 1108 chemicals present in 228 consumer product types. It includes toxicokinetics considerations to estimate body burden. It includes a simple framework for rapid modeling of broad changes in consumer use patterns by product category. Ex Priori rapidly models changes in consumer user patterns during the COVID-

SUBMITTER: Hubbard HF 

PROVIDER: S-EPMC9609548 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature