Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review.

ABSTRACT: Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. As such, the controlled activation of macrophages and modulation of their phenotype through implant surface modification has emerged as a key therapeutic strategy.

Methods

Online databases were searched for in vitro studies between January 1991 and June 2020 which examined the effect of titanium implant surface topography on the adherent macrophage phenotype at either the gene or protein level.

Results

Thirty-nine studies were subsequently included for review. Although there was significant heterogeneity between studies, treatment of titanium surfaces increased

SUBMITTER: Pitchai M 

PROVIDER: S-EPMC9609829 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature