Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.
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ABSTRACT:
SUBMITTER: Monteiro NO
PROVIDER: S-EPMC9609921 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats.
Monteiro Noemi Oliveira NO Monteiro Theresa de Moura TM Nogueira Thalya Soares R TSR Cesar Jacqueline Rodrigues JR Nascimento Lara Pessanha S LPS Campelo Karoline Azerêdo KA Silveira Graziela Rangel GR Antunes Fernanda F de Oliveira Daniela Barros DB de Carvalho Junior Almir Ribeiro AR Braz-Filho Raimundo R Vieira Ivo José Curcino IJC
Molecules (Basel, Switzerland) 20221014 20
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS). The antihypertensive activity was investigated by intravenous infusion in Wistar rats. This alkaloid significantly reduced (p < 0.05) the systolic, median, and diastolic blood pressures of rodents, without causing motor incoordination and imbalance in the rotarod test. The results indicat ...[more]
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