Physical activity moderates the association between white matter hyperintensity burden and cognitive change.

ABSTRACT:

Objective

Greater physical activity (PA) could delay cognitive decline, yet the underlying mechanisms remain unclear. White matter hyperintensity (WMH) burden is one of the key brain pathologies that have been shown to predict faster cognitive decline at a late age. One possible pathway is that PA may help maintain cognition by mitigating the detrimental effects of brain pathologies, like WMH, on cognitive change. This study aims to examine whether PA moderates the association between WMH burden and cognitive change.

Materials and methods

This population-based longitudinal study included 198 dementia-free adults aged 20-80 years. Leisure-time physical activity (LTPA) was assessed by a self-reported questionnaire. Occupational physical activity (OPA) was a factor score measur

SUBMITTER: Song S 

PROVIDER: S-EPMC9610117 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature