Reservoir-Style Polymeric Drug Delivery Systems: Empirical and Predictive Models for Implant Design.

ABSTRACT: Controlled drug delivery systems can provide sustained release profiles, favorable pharmacokinetics, and improved patient adherence. Here, a reservoir-style implant comprising a biodegradable polymer, poly(ε-caprolactone) (PCL), was developed to deliver drugs subcutaneously. This work addresses a key challenge when designing these implantable drug delivery systems, namely the accurate prediction of drug release profiles when using different formulations or form factors of the implant. The ability to model and predict the release behavior of drugs from an implant based on their physicochemical properties enables rational design and optimization without extensive and laborious in vitro testing. By leveraging experimental observations, we propose a mathematical model that predicts the empiric

SUBMITTER: Li L 

PROVIDER: S-EPMC9610229 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature