Genome-Wide Association Study of Listeria monocytogenes Isolates Causing Three Different Clinical Outcomes.

ABSTRACT: Heterogeneity in virulence potential of L. monocytogenes subgroups have been associated with genetic elements that could provide advantages in certain environments to invade, multiply, and survive within a host. The presence of gene mutations has been found to be related to attenuated phenotypes, while the presence of groups of genes, such as pathogenicity islands (PI), has been associated with hypervirulent or stress-resistant clones. We evaluated 232 whole genome sequences from invasive listeriosis cases in human and ruminants from the US and Europe to identify genomic elements associated with strains causing three clinical outcomes: central nervous system (CNS) infections, maternal-neonatal (MN) infections, and systemic infections (SI). Phylogenetic relationships and virulence-as

SUBMITTER: Cardenas-Alvarez MX 

PROVIDER: S-EPMC9610272 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature