Characterisation of the Theileria orientalis Piroplasm Proteome across Three Common Genotypes.

ABSTRACT: Theileria orientalis is an emerging apicomplexan pathogen of cattle occurring in areas populated by the principal vector tick, Haemaphysalis longicornis. Unlike transforming Theileria spp. that induce cancer-like proliferation of lymphocytes via their schizont stage, T. orientalis destroys host erythrocytes during its piroplasm phase resulting in anaemia. The underlying pathogenic processes of T. orientalis infection are poorly understood; consequently, there are no vaccines for prevention of T. orientalis infection and chemotherapeutic options are limited. To identify antigens expressed during the piroplasm phase of T. orientalis, including those which may be useful targets for future therapeutic development, we examined the proteome across

SUBMITTER: Jenkins C 

PROVIDER: S-EPMC9610513 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature