Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice.

ABSTRACT: Background: Neuronal apoptosis is a major contributor to Alzheimer's disease (AD). Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas gingivalis and Treponema denticola have been shown to initiate the hallmark pathologies and behavioral symptoms of AD. Studies have found that T. denticola infection induced Tau hyperphosphorylation and amyloid β accumulation in the hippocampi of mice. Aβ accumulation is closely associated with neuronal apoptosis. However, the roles of T. denticola in neuronal apoptosis remain unclear and its roles in AD pathology need further study. Objective: This study aimed to investigate whether oral infection with T. denticola induced alveolar bone loss and neuronal apoptosis in mi

SUBMITTER: Wu L 

PROVIDER: S-EPMC9610539 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature