Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin.

ABSTRACT: The importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop a less hemolytic peptide with anti-neuroinflammatory, antibacterial, and cytotoxic activity against tumor cells. In silico and in vitro studies were performed at various concentrations. Ca-MAP1 exhibits low hemolytic activity

SUBMITTER: Cardoso PHO 

PROVIDER: S-EPMC9610734 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature