Sex hormones, body mass index, and related comorbidities associated with developing Sjogren's disease: a nested case-control study.

ABSTRACT:

Objective

Sjögren's disease (SjD), a highly female predominant systemic autoimmune disease, peaks in perimenopause. Prior studies lack details on timing or type of sex hormone exposure. We examined SjD risk using endogenous and exogenous hormone exposure and related comorbidities.

Methods

We performed a retrospective case-control study of adult women, nested within a population cohort. Cases had SjD diagnosed by a rheumatology provider or two SjD diagnoses from a non-rheumatology provider with a positive anti-SSA antibody or salivary gland biopsy. Cases were age-matched to three SjD-free controls. We calculated modified composite estrogen scores (mCES) and collected demographics, comorbidities, and endogenous and exogenous hormone exposures. Risk ratios were adjusted for dem

SUBMITTER: McCoy SS 

PROVIDER: S-EPMC9610811 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature