Metal Coordination Effects on the Photophysics of Dipyrrinato Photosensitizers.

ABSTRACT: Within this work, we review the metal coordination effect on the photophysics of metal dipyrrinato complexes. Dipyrrinato complexes are promising candidates in the search for alternative transition metal photosensitizers for application in photodynamic therapy (PDT). These complexes can be activated by irradiation with light of a specific wavelength, after which, cytotoxic reactive oxygen species (ROS) are generated. The metal coordination allows for the use of the heavy atom effect, which can enhance the triplet generation necessary for generation of ROS. Additionally, the flexibility of these complexes for metal ions, substitutions and ligands allows the possibility to tune their photophysical properties. A general overview of the mechanism of photodynamic therapy and the properties of t

SUBMITTER: Teeuwen PCP 

PROVIDER: S-EPMC9610856 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature