Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance.

ABSTRACT: The dialyzer is the core element in the hemodialysis treatment of patients with end-stage kidney disease (ESKD). During hemodialysis treatment, the dialyzer replaces the function of the kidney by removing small and middle-molecular weight uremic toxins, while retaining essential proteins. Meanwhile, a dialyzer should have the best possible hemocompatibility profile as the perpetuated contact of blood with artificial surfaces triggers complement activation, coagulation and immune cell activation, and even low-level activation repeated chronically over years may lead to undesired effects. During hemodialysis, the adsorption of plasma proteins to the dialyzer membrane leads to a formation of a secondary membrane, which can compromise both the uremic toxin removal and hemocompatibility of the

SUBMITTER: Zawada AM 

PROVIDER: S-EPMC9610916 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature