Bio-Activation of HA/β-TCP Porous Scaffolds by High-Pressure CO₂ Surface Remodeling: A Novel "Coating-from" Approach.

ABSTRACT: Biphasic macroporous Hydroxyapatite/β-Tricalcium Phosphate (HA/β-TCP) scaffolds (BCPs) are widely used for bone repair. However, the high-temperature HA and β-TCP phases exhibit limited bioactivity (low solubility of HA, restricted surface area, low ion release). Strategies were developed to coat such BCPs with biomimetic apatite to enhance bioactivity. However, this can be associated with poor adhesion, and metastable solutions may prove difficult to handle at the industrial scale. Alternative strategies are thus desirable to generate a highly bioactive surface on commercial BCPs. In this work, we developed an innovative "coating from" approach for BCP surface remodeling via hydrothermal treatment under supercritical CO₂, used as a reversible pH modifier and with industrial sca

SUBMITTER: Aubry C 

PROVIDER: S-EPMC9610974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature