Synthesis and Biological Activity of Novel Oxazinyl Flavonoids as Antiviral and Anti-Phytopathogenic Fungus Agents.

ABSTRACT: A series of oxazinyl flavonoids were synthesized on the basis of flavone. The structures of all target compounds were characterized by ¹H NMR, ¹³C NMR, and HRMS. The effect of the different substituent on the N-position of oxazinyl flavonoids against tobacco mosaic virus (TMV) activities and plant pathogen activities was systematically investigated. In vivo anti-TMV activity showed that most of the compounds showed moderate-to-excellent antiviral activities against TMV at 500 μg/mL. Compounds 6b, 6d, 6j-6k, and 6n-6q showed better antiviral activities than ribavirin (a commercially available antiviral agent) and apigenin. In particular, compounds 6n and 6p even displayed slightly higher activities than ningnanmyc

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9611556 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature