Sustained Drug Release from Smart Nanoparticles in Cancer Therapy: A Comprehensive Review.

ABSTRACT: Although nanomedicine has been highly investigated for cancer treatment over the past decades, only a few nanomedicines are currently approved and in the market; making this field poorly represented in clinical applications. Key research gaps that require optimization to successfully translate the use of nanomedicines have been identified, but not addressed; among these, the lack of control of the release pattern of therapeutics is the most important. To solve these issues with currently used nanomedicines (e.g., burst release, systemic release), different strategies for the design and manufacturing of nanomedicines allowing for better control over the therapeutic release, are currently being investigated. The inclusion of stimuli-responsive properties and prolonged drug release have been

SUBMITTER: Bai X 

PROVIDER: S-EPMC9611581 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature