Pre-Pandemic Cross-Reactive Immunity against SARS-CoV-2 among Central and West African Populations.

ABSTRACT: For more than two years after the emergence of COVID-19 (Coronavirus Disease-2019), significant regional differences in morbidity persist. These differences clearly show lower incidence rates in several regions of the African and Asian continents. The work reported here aimed to test the hypothesis of a pre-pandemic natural immunity acquired by some human populations in central and western Africa, which would, therefore, pose the hypothesis of an original antigenic sin with a virus antigenically close to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). To identify such pre-existing immunity, sera samples collected before the emergence of COVID-19 were tested to detect the presence of IgG reacting antibodies against SARS-CoV-2 proteins of major significance. Sera samples fr

SUBMITTER: Souris M 

PROVIDER: S-EPMC9611584 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature