Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts.

ABSTRACT: Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson's disease (PD) affects 10 million people worldwide and is associated with α-synuclein misfolding, also found in other pathologies collectively called synucleinopathies. Here, we show that aqueous extracts of two edible mushrooms, Grifola frondosa and Hericium erinaceus, represent a valuable source of β-glucans and exert anti-aging effects in yeast. Their beneficial effects are mediated through the inhibition of the Ras/PKA pathway, with increased expressio

SUBMITTER: Tripodi F 

PROVIDER: S-EPMC9611596 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature