Potential of Essential Oil-Based Anticholinesterase Insecticides against Anopheles Vectors: A Review.

ABSTRACT: The insect nervous system is critical for its functional integrity. The cholinergic system, of which acetylcholinesterase (AChE) is a key enzyme, is essential to the Anopheles (consisting of major malaria vector species) nervous system. Furthermore, the nervous system is also the primary target site for insecticides used in malaria vector control programs. Insecticides, incorporated in insecticide-treated nets and used for indoor residual spraying, are a core intervention employed in malaria vector control. However, Anopheles resistance against these insecticides has grown rapidly. Due to this major setback, novel agents with potential activity against resistant Anopheles and/or capacity to overcome resistance against current WHO-approved insecticides are urgently need

SUBMITTER: Rants'o TA 

PROVIDER: S-EPMC9611659 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature