Resistance and Susceptibility Immune Factors at Play during Mycobacterium tuberculosis Infection of Macrophages.

ABSTRACT: Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (M.tb), is responsible for >1.5 million deaths worldwide annually. Innate immune cells, especially macrophages, are the first to encounter M.tb, and their response dictates the course of infection. During infection, macrophages exert a variety of immune factors involved in either controlling or promoting the growth of M.tb. Research on this topic has been performed in both in vitro and in vivo animal models with discrepant results in some cases based on the model of study. Herein, we review macrophage resistance and susceptibility immune factors, focusing primarily on recent advances in the field. We include macrophage cellular pathways, bioeffector proteins and molecules, cytokines and chemokines, associated microbiolo

SUBMITTER: Simper JD 

PROVIDER: S-EPMC9611686 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature