Capsaicin Ameliorates High-Fat Diet-Induced Atherosclerosis in ApoE^-/- Mice via Remodeling Gut Microbiota.

ABSTRACT: Capsaicin is a pungent alkaloid abundantly present in peppers with outstanding biological activities, including the anti-atherosclerosis effect. Previous studies revealed that gut microbiota played an important role in the beneficial effects of capsaicin, but whether it is essential for the anti-atherosclerosis effect of capsaicin is unclear. This study evaluated the anti-atherosclerosis effect of capsaicin in ApoE^-/- mice and further explored the role of depleting gut microbiota in the improvement of atherosclerosis. The results showed that capsaicin administration could prevent the development of atherosclerosis and improve serum lipids and inflammation, while antibiotic intervention abolished the alleviation of atherosclerosis by capsaicin. In addition, capsaicin administrati

SUBMITTER: Dai Z 

PROVIDER: S-EPMC9611743 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature