Differential Metabolism of Glycerol Based on Oral versus Intravenous Administration in Humans.

ABSTRACT: Glycerol can be metabolized to glucose via gluconeogenesis or lactate via glycolysis. It is unknown if glycerol is metabolized similarly in the portal and systemic circulations in humans. Eight metabolically healthy overnight-fasted individuals received equimolar amounts of ¹³C₃-glycerol orally and intravenously on two separate occasions with serial blood draws over four hours. Serum samples underwent liquid chromatography-mass spectrometry analysis. Oral ¹³C₃-glycerol administration led to higher average serum glucose enrichment than intravenous administration (5.02 ± 1.43 versus 4.07 ± 0.79%, p = 0.009). In contrast, intravenous ¹³C₃-glycerol administration yielded higher average serum lactate enrichment than oral a

SUBMITTER: Shah A 

PROVIDER: S-EPMC9611849 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature