Reporter Transgenes for Monitoring the Antitumor Efficacy of Recombinant Oncolytic Viruses.

ABSTRACT: Accurate measurement of tumor size and margins is crucial for successful oncotherapy. In the last decade, non-invasive imaging modalities, including optical imaging using non-radioactive substrates, deep-tissue imaging with radioactive substrates, and magnetic resonance imaging have been developed. Reporter genes play the most important role among visualization tools; their expression in tumors and metastases makes it possible to track changes in the tumor growth and gauge therapy effectiveness. Oncolytic viruses are often chosen as a vector for delivering reporter genes into tumor cells, since oncolytic viruses are tumor-specific, meaning that they infect and lyse tumor cells without damaging normal cells. The choice of reporter transgenes for genetic modification of oncolytic viruses dep

SUBMITTER: Semenova AV 

PROVIDER: S-EPMC9611865 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature