Platinum(IV) Complexes of the 1,3,5-Triamino Analogue of the Biomolecule Cis-Inositol Designed as Innovative Antineoplastic Drug Candidates.

ABSTRACT: Metal complexes occupy a special place in the field of treatment and diagnostics. Their main advantages stem from the possibility of fine-tuning their thermodynamic properties and kinetic behavior in the biological milieu by applying different approaches such as properly constructed inner coordination sphere, appropriate choice of ligands, metal oxidation state, redox potential, etc., which are specific to these compounds. Here we discuss the design and synthesis of two octahedral cationic Pt(IV) complexes of the tridentate ligand all-cis-2,4,6-triaminocyclohexane-1,3,5-triol (taci) with composition, fac-[Pt(taci)I₃]⁺, 1 and bis-[Pt(taci)₂]⁴⁺, 2 as well as the potential for their application as antineoplastic ag

SUBMITTER: Velcheva V 

PROVIDER: S-EPMC9611922 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature