Epigenetics in Tuberculosis: Immunomodulation of Host Immune Response.

ABSTRACT: Tuberculosis is a stern, difficult to treat chronic infection caused by acid-fast bacilli that tend to take a long time to be eradicated from the host's environment. It requires the action of both innate and adaptive immune systems by the host. There are various pattern recognition receptors present on immune cells, which recognize foreign pathogens or its product and trigger the immune response. The epigenetic modification plays a crucial role in triggering the susceptibility of the host towards the pathogen and activating the host's immune system against the invading pathogen. It alters the gene expression modifying the genetic material of the host's cell. Epigenetic modification such as histone acetylation, alteration in non-coding RNA, DNA methylation and alteration in miRNA has been s

SUBMITTER: Khadela A 

PROVIDER: S-EPMC9611989 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature