Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 M^Pro, S^Pro, and RdRp: A Pharmacological Perspective.

ABSTRACT: The tracing of an alternative drug, Phytochemicals is a promising approach to the viral threats that have emerged over the past two years. Across the world, herbal medicine is a better solution against anti-viral diseases during pandemic periods. Goniothalamus wightii is an herbal plant, which has diverse bioactive compounds with anticancer, antioxidant, and anti-viral properties. The aim of the study was to isolate the compound by chromatography studies and functionalization by FT-IR, LC-MS, and NMR (C-NMR, H-NMR). As a result, the current work focuses on whether (S)-Goniathalamin and its analogue could act as natural anti-viral molecules for multiple target proteins viz., M^Pro, RdRp, and S^Pro, which are required for SARS-CoV-2 infection. Overall, 954 compound

SUBMITTER: Palani V 

PROVIDER: S-EPMC9612040 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature