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Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study.

ABSTRACT: Background: Inconsistent epidemiological evidence between uric acid (UA) and bone mineral density (BMD) has been observed. Therefore, we evaluated the association between UA and BMD in Mexican adults. Methods: This analysis was conducted on 1423 participants from the Health Workers Cohort Study. We explored cross-sectional associations using linear regression and longitudinal associations using fixed-effects linear regression by sex and age groups (<45 and ≥45 years). Results: In females <45 years old, the cross-sectional analysis showed that UA levels were positively associated with total hip BMD. However, in the longitudinal analysis, we observed a negative association with the femoral neck and lumbar spine BMD. In contrast, in males <45 years old, we found an increase in total hip and femoral neck BMD in the groups with high levels of UA in the longitudinal association. On the other hand, in females ≥45 years old, we observed a longitudinal association between UA and loss of BMD at different sites. We did not observe an association between UA levels and BMD in males ≥45 years old. Conclusions: Our results suggest higher serum UA levels are associated with low BMD at different skeletal sites in Mexican females. Further studies are needed to delineate the underlying mechanisms behind this observation.

SUBMITTER: Robles-Rivera K

PROVIDER: S-EPMC9612067 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study.

Robles-Rivera Karina K Argoty-Pantoja Anna D AD Hidalgo-Bravo Alberto A Quezada-Sánchez Amado D AD León-Reyes Guadalupe G Flores Yvonne N YN Salmerón Jorge J Velázquez-Cruz Rafael R Rivera-Paredez Berenice B

Nutrients 20221012 20

Background: Inconsistent epidemiological evidence between uric acid (UA) and bone mineral density (BMD) has been observed. Therefore, we evaluated the association between UA and BMD in Mexican adults. Methods: This analysis was conducted on 1423 participants from the Health Workers Cohort Study. We explored cross-sectional associations using linear regression and longitudinal associations using fixed-effects linear regression by sex and age groups (<45 and ≥45 years). Results: In females <45 yea ...[more]

PMID: 36296929

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Project description:Despite extensive studies conducted on the relationship between serum uric acid (UA) and bone mineral density (BMD), their association remains controversial. In this study, we investigated whether UA levels are independently associated with BMD in Chinese and American populations to elucidate their association. Herein, the data of 12,344 individuals (age > 20 years) from the National Health and Nutrition Examination Survey (2005-2018) and those of 768 individuals from the inpatient medical records and physical examination center systems of the Tertiary Class A Hospital (2021-2023) from China were included. The association between UA and BMD was analyzed by employing multivariate regression models with covariate adjustments. In addition, population description, stratified analysis, single-factor analysis, smooth-curve fitting, and threshold and saturation effect analyses were performed. After covariate adjustments, UA exhibited an association with BMD of the femur (β = 0.008, 95% confidence interval [CI] 0.001-0.015, P = 0.02), femoral neck (β = 0.011, 95% CI 0.004-0.018, P = 0.002), and lumbar spine (β = 0.014, 95% CI 0.06-0.022, P < 0.001) in American subjects. Similarly, UA exhibited association with BMD of the femur (β = 0.079, 95% CI 0.042-0.117, P < 0.001), femoral neck (β = 0.171, 95% CI 0.121-0.22, P < 0.001), and lumbar spine (β = 0.052, 95% CI 0.007-0.097, P = 0.024) in Chinese subjects. Notably, the relationship between UA levels and BMD was nonlinear. The saturated utility values for determining the UA level with BMD of the femur and femoral neck using a two-stage linear regression model were 429.9 and 468 μmol/L, respectively, in the Chinese population. In the American population, the saturated utility values of UA level with BMD of the femur, femoral neck, and lumbar spine were 410.4, 410.4, and 452 μmol/L, respectively. Altogether, the present findings suggested a positive association between the UA levels and overall BMD in adults, implying that maintaining saturated UA levels can facilitate osteoporosis prevention.China Clinical Trials Registry: MR-51-23-051741. https://www.medicalresearch.org.cn/search/research/researchViewid=c0e5f868-eca9-4c68-af58-d73460c34028 .

Project description:UnlabelledWe hypothesized that chronic exposures to traffic combustion products may lower bone mineral density (BMD). We found that proximity to freeways was associated with reduced BMD. Our findings suggest that traffic-related pollution may contribute to the occurrence of osteopenia and osteoporosis.IntroductionAdults residing in rural areas have been linked with higher BMD. We aimed to determine if this difference is due in part to air pollution by examining the relationships between traffic metrics and ambient air pollution with total body and pelvic BMD.MethodsMexican American adults (n = 1,175; mean 34 years; 72 % female) who had participated in the BetaGene study of air pollution, obesity, and insulin resistance were included in this analysis. Total body and pelvic BMD were estimated using dual-energy X-ray absorptiometry. Traffic and ambient air pollutant exposures were estimated at residences using location and ambient monitoring data. Variance component models were used to analyze the associations between residential distance to the nearest freeway and ambient air pollutants with BMD.ResultsResidential proximity to a freeway was associated with lower total body BMD (p-trend = 0.01) and pelvic BMD (p-trend = 0.03) after adjustment for age, sex, weight, and height. The adjusted mean total body and pelvic BMD in participants living within 500 m of a freeway were 0.02 and 0.03 g/cm(2) lower than participants living greater than 1,500 m from a freeway. These associations did not differ significantly by age, sex, or obesity status. Results were similar after further adjustment for body fat and weekly physical activity minutes. Ambient air pollutants (NO2, O3, and PM2.5) were not significantly associated with BMD.ConclusionsTraffic-related exposures in overweight and obese Mexican Americans may adversely affect BMD. Our findings indicate that long-term exposures to traffic may contribute to the occurrence of osteoporosis and its consequences.

Dataset Information

Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study.

Publications

Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study.

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