Transforming Growth Factor-β Concerning Malarial Infection and Severity: A Systematic Review and Meta-Analysis.

ABSTRACT: Transforming growth factor-β (TGF-β) is important in the pathophysiology of malaria, but its role in acute and severe malaria is largely unknown. As a result, this study used a meta-analysis approach to investigate the difference in TGF-β levels between several groups of malaria patients and healthy controls. The systematic review protocol was registered at PROSPERO (ID: CRD42022318864). From inception to 7 March 2022, studies that reported TGF-β levels in patients with uncomplicated and healthy controls and patients with severe and uncomplicated malaria were searched in PubMed, Scopus and Embase. The assessment of the quality of the included studies was conducted according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines. Qualitative and quantitative

SUBMITTER: Kotepui KU 

PROVIDER: S-EPMC9612234 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature