Untargeted Metabolomic Approach to Study the Impact of Aging on Salivary Metabolome in Women.

ABSTRACT: Despite the growing interest in salivary metabolomics, few studies have investigated the impact of aging on the salivary metabolome. The alterations in metabolic pathways that occur with aging are likely to be observed in pathologies affecting older people and may interfere with the search for salivary biomarkers. It is therefore important to investigate the age-related changes occurring in the salivary metabolome. Using reversed phase liquid chromatography and hydrophilic interaction chromatography coupled to mass spectrometry used in positive and negative ionization modes, the salivary metabolic profiles of young (22 to 45 years old) and older people (55 to 92 years old) were obtained. Those profiles were compared with the use of XCMS online to highlight the under or overexpression of so

SUBMITTER: Bosman P 

PROVIDER: S-EPMC9612358 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature