Systematic Review and Meta-Analysis on Human African Trypanocide Resistance.

ABSTRACT: Background Human African trypanocide resistance (HATr) is a challenge for the eradication of Human African Trypansomiaisis (HAT) following the widespread emergence of increased monotherapy drug treatment failures against Trypanosoma brucei gambiense and T. b. rhodesiense that are associated with changes in pathogen receptors.

Methods

Electronic searches of 12 databases and 3 Google search websites for human African trypanocide resistance were performed using a keyword search criterion applied to both laboratory and clinical studies. Fifty-one publications were identified and included in this study using the PRISMA checklist. Data were analyzed using RevMan and random effect sizes were computed for the statistics at the 95% confidence interval.

Result

SUBMITTER: Kasozi KI 

PROVIDER: S-EPMC9612373 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature