Can Radiomics Provide Additional Information in [¹⁸F]FET-Negative Gliomas?

ABSTRACT: The purpose of this study was to evaluate the possibility of extracting relevant information from radiomic features even in apparently [¹⁸F]FET-negative gliomas. A total of 46 patients with a newly diagnosed, histologically verified glioma that was visually classified as [¹⁸F]FET-negative were included. Tumor volumes were defined using routine T2/FLAIR MRI data and applied to extract information from dynamic [¹⁸F]FET PET data, i.e., early and late tumor-to-background (TBR_5-15, TBR_20-40) and time-to-peak (TTP) images. Radiomic features of healthy background were calculated from the tumor volume of interest mirrored in the contralateral hemisphere. The ability to distinguish tumors from healthy tissue was assessed using the Wilcoxon test

SUBMITTER: von Rohr K 

PROVIDER: S-EPMC9612387 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature