Prior antibiotics and risk of subsequent Herpes zoster: A population-based case control study.

ABSTRACT:

Background

The effect of antibiotics on the human microbiome is now well established, but their indirect effect on the related immune response is less clear. The possible association of Herpes zoster, which involves a reactivation of a previous varicella zoster virus infection, with prior antibiotic exposure might indicate a potential link with the immune response.

Methods

A case-control study was carried out using a clinical database, the UK's Clinical Practice Research Datalink. A total of 163,754 patients with varicella zoster virus infection and 331,559 age/sex matched controls were identified and their antibiotic exposure over the previous 10 years, and longer when data permitted, was identified. Conditional logistic regression was used to identify the association betwe

SUBMITTER: Armstrong D 

PROVIDER: S-EPMC9612511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature