Brain and spinal cord paired stimulation coupled with locomotor training facilitates motor output in human spinal cord injury.

ABSTRACT: Combined interventions for neuromodulation leading to neurorecovery have gained great attention by researchers to resemble clinical rehabilitation approaches. In this randomized clinical trial, we established changes in the net output of motoneurons innervating multiple leg muscles during stepping when transcranial magnetic stimulation (TMS) of the primary motor cortex was paired with transcutaneous spinal (transspinal) stimulation over the thoracolumbar region during locomotor training. TMS was delivered before (TMS-transspinal) or after (transspinal-TMS) transspinal stimulation during the stance phase of the less impaired leg. Ten individuals with chronic incomplete or complete SCI received at least 20 sessions of training. Each session consisted of 240 paired stimuli delivered over 10-m

SUBMITTER: Pulverenti TS 

PROVIDER: S-EPMC9612520 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature