Using the Collaborative Cross and Diversity Outbred Mice in Immunology.

ABSTRACT: The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels are the most powerful murine genetics tools available to the genetics community. Together, they combine the strength of inbred animal models with the diversity of outbred populations. Using the 63 CC strains or a panel of DO mice, each derived from the same 8 parental mouse strains, researchers can map genetic contributions to exceptionally complex immunological and infectious disease traits that would require far greater powering if performed by genome-wide association studies (GWAS) in human populations. These tools allow genes to be studied in heterozygous and homozygous states and provide a platform to study epistasis between interacting loci. Most importantly, once a quantitative phenotype is investigated a

SUBMITTER: Hackett J 

PROVIDER: S-EPMC9612550 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature