Abnormalities in the migration of neural precursor cells in familial bipolar disorder.

ABSTRACT: Cellular migration is a ubiquitous feature that brings brain cells into appropriate spatial relationships over time; and it helps in the formation of a functional brain. We studied the migration patterns of induced pluripotent stem cell-derived neural precursor cells (NPCs) from individuals with familial bipolar disorder (BD) in comparison with healthy controls. The BD patients also had morphological brain abnormalities evident on magnetic resonance imaging. Time-lapse analysis of migrating cells was performed, through which we were able to identify several parameters that were abnormal in cellular migration, including the speed and directionality of NPCs. We also performed transcriptomic analysis to probe the mechanisms behind the aberrant cellular phenotype identified. Our analysis showe

SUBMITTER: Sukumaran SK 

PROVIDER: S-EPMC9612872 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature