Postsynaptic burst reactivation of hippocampal neurons enables associative plasticity of temporally discontiguous inputs.

ABSTRACT: A fundamental unresolved problem in neuroscience is how the brain associates in memory events that are separated in time. Here, we propose that reactivation-induced synaptic plasticity can solve this problem. Previously, we reported that the reinforcement signal dopamine converts hippocampal spike timing-dependent depression into potentiation during continued synaptic activity (Brzosko et al., 2015). Here, we report that postsynaptic bursts in the presence of dopamine produce input-specific LTP in mouse hippocampal synapses 10 min after they were primed with coincident pre- and post-synaptic activity (post-before-pre pairing; Δt = -20 ms). This priming activity induces synaptic depression and sets an NMDA receptor-dependent silent eligibility trace which, through the cAMP-PKA cascade, is r

SUBMITTER: Fuchsberger T 

PROVIDER: S-EPMC9612916 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature