Cerebral Blood Flow in the Salience Network of Individuals with Alcohol Use Disorder.

ABSTRACT:

Aims

Magnetic resonance imaging (MRI) studies have identified structural and functional differences in salience network nodes of individuals with alcohol use disorders (AUDs) after chronic exposure to alcohol. However, no studies have investigated cerebral blood flow (CBF) in nontreatment-seeking (NTS) individuals with AUD.

Methods

In this work, we sought to quantify putative CBF deficits in NTS individuals relative to social drinking (SD) controls and determine if CBF in the salience network is associated with AUD severity. Fifteen NTS (36.5 ± 11.2 years old, 30.0 ± 22.7 drinks/week) and 22 SD (35.6 ± 11.9 years old, 9.1 ± 5.7 drinks/week) underwent pseudocontinuous arterial spin labeling MRI.

Results

Compared with social drinkers, NTS individuals had significantly l

SUBMITTER: Butcher TJ 

PROVIDER: S-EPMC9613478 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature