Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation.

ABSTRACT:

Background

Complement activation after trauma promotes hemostasis but is associated with increased morbidity and mortality. However, the specific pathways and downstream mediators remain unclear. Recently, the anaphylatoxin C4a has been shown to bind to thrombin receptors. While plasma-based resuscitation has been shown to modify the endotheliopathy of trauma, it may provide complement zymogens that fuel ongoing inflammatory cascades. We sought to characterize the activation of complement after injury and the effect of fresh frozen plasma (FFP) on this inflammatory response. We hypothesized that trauma induces C4 activation, which is associated with worse outcomes and influenced by FFP resuscitation.

Methods

Blood was collected from injured patients at a single level I traum

SUBMITTER: Schaid TR 

PROVIDER: S-EPMC9613483 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature