A Liquid Biopsy Signature for the Detection of Patients With Early-Onset Colorectal Cancer.

ABSTRACT:

Background & aims

Early-onset colorectal cancer (EOCRC) is a distinct clinical and molecular entity with poor survival outcomes compared with late-onset CRC. Although the incidence of EOCRC is rising, current CRC screening strategies have several limitations in diagnostic performance for EOCRC. In view of this clinical challenge, novel and robust biomarkers for detection of EOCRC are necessary. The aim of this study was to develop a circulating micro RNA (miRNA) signature for the diagnosis of patients with EOCRC.

Methods

A systematic discovery approach by analyzing a large, publicly available, noncoding RNA expression profiling dataset (GSE115513) was used. A panel of miRNAs was identified, which was subsequently validated in blood samples from patients with EOCRC in 2 indep

SUBMITTER: Nakamura K 

PROVIDER: S-EPMC9613521 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature