A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond.

ABSTRACT:

Objective

To summarize the pharmacology of the calcitonin peptide family of receptors and explore their relationship to migraine and current migraine therapies.

Background

Therapeutics that dampen calcitonin gene-related peptide (CGRP) signaling are now in clinical use to prevent or treat migraine. However, CGRP belongs to a broader peptide family, including the peptides amylin and adrenomedullin. Receptors for this family are complex, displaying overlapping pharmacologic profiles. Despite the focus on CGRP and the CGRP receptor in migraine research, recent evidence implicates related peptides and receptors in migraine.

Methods

This narrative review summarizes literature encompassing the current pharmacologic understanding of the calcitonin peptide family, and the evi

SUBMITTER: Garelja ML 

PROVIDER: S-EPMC9613588 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature