Pregnancy in Women With HIV in a Tuberculosis Preventive Therapy Trial.

ABSTRACT:

Background

Tuberculosis preventive therapy (TPT) is recommended for people with HIV infection, including during pregnancy. The effect of TPT exposure at conception and during pregnancy is poorly documented.

Methods

We report pregnancy outcomes among South African women with HIV enrolled in a randomized trial of 4 TPT regimens (two 3-month regimens, rifapentine/isoniazid [3HP] or rifampin/isoniazid [3HR], isoniazid for 6 months, or isoniazid continuously). Descriptive statistics and risk ratios were assessed to examine relationships between study regimens and outcomes.

Results

216/896 women (24%) conceived during the study. Women who conceived were younger (27.9 vs 31.3 years) and had higher mean CD4 counts (589.1 vs 536.7). The odds of pregnancy were higher in women i

SUBMITTER: Singh P 

PROVIDER: S-EPMC9613590 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature