Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila.

ABSTRACT: Effective and stimulus-specific learning is essential for animals' survival. Two major mechanisms are known to aid stimulus specificity of associative learning. One is accurate stimulus-specific representations in neurons. The second is a limited effective temporal window for the reinforcing signals to induce neuromodulation after sensory stimuli. However, these mechanisms are often imperfect in preventing unspecific associations; different sensory stimuli can be represented by overlapping populations of neurons, and more importantly, the reinforcing signals alone can induce neuromodulation even without coincident sensory-evoked neuronal activity. Here, we report a crucial neuromodulatory mechanism that counteracts both limitations and is thereby essential for stimulus specificity of learn

SUBMITTER: Manoim JE 

PROVIDER: S-EPMC9613607 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature