Regional cytoarchitecture of the adult and developing mouse enteric nervous system.

ABSTRACT: The organization and cellular composition of tissues are key determinants of their biological function. In the mammalian gastrointestinal (GI) tract, the enteric nervous system (ENS) intercalates between muscular and epithelial layers of the gut wall and can control GI function independent of central nervous system (CNS) input.¹ As in the CNS, distinct regions of the GI tract are highly specialized and support diverse functions, yet the regional and spatial organization of the ENS remains poorly characterized.² Cellular arrangements,^3,4 circuit connectivity patterns,^5,6 and diverse cell types^7-9 are known to underpin ENS functional complexity and GI function, but enteric neurons are most typi

SUBMITTER: Hamnett R 

PROVIDER: S-EPMC9613618 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature