Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.

ABSTRACT: Airway inflammation and remodelling are important pathophysiologic features in asthma and other respiratory conditions. An intact epithelial cell layer is crucial to maintain lung homoeostasis, and this depends on intercellular adhesion, whilst damaged respiratory epithelium is the primary instigator of airway inflammation. The Coxsackievirus Adenovirus Receptor (CAR) is highly expressed in the epithelium where it modulates cell-cell adhesion stability and facilitates immune cell transepithelial migration. However, the contribution of CAR to lung inflammation remains unclear. Here we investigate the mechanistic contribution of CAR in mediating responses to the common aeroallergen, House Dust Mite (HDM). We demonstrate that administration of HDM in mice lacking CAR in the respiratory epithe

SUBMITTER: Ortiz-Zapater E 

PROVIDER: S-EPMC9613683 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature