Sensing nitriles with THz spectroscopy of urine vapours from cancers patients subject to chemotherapy.

ABSTRACT: A THz nonstationary high-resolution spectrometer based on semiconductor superlattice multipliers is applied to investigate the dynamics of urine composition for cancer patients treated with chemotherapy. The molecular urine composition of healthy volunteers and cancer patients was compared and contrasted. We have found a set of nitriles that either appeared after chemotherapy or increased in content, which are expected as a result of bio-chemical damage to the liver. While no damage can be detected at this stage by existing clinical methods, the identified nitriles are candidates for further large-scale systematic testing towards markers for nephrotoxicity of chemotherapy at an early stage of the treatment, when conventional diagnostics cannot identify substantial organ damage. Comparing t

SUBMITTER: Vaks V 

PROVIDER: S-EPMC9613899 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature