Utilization of ex vivo tissue model to study skin regeneration following microneedle stimuli.

ABSTRACT: Microneedling is a popular skin resurfacing and rejuvenation procedure. In order to develop better adjunct products for consumers, there is a scientific need to establish greater understanding of the mechanism in which microneedling stimulates regeneration within skin. The purpose of this study is to develop a physiologically relevant ex vivo tissue model which closely mimics the actual microneedling procedure to elucidate its mechanism of action. In this study, human ex vivo skin was subjected to microneedling treatment and cultured for 6 days. Histological analysis demonstrated that the ex vivo skin was able to heal from microneedling injury throughout the culture period. Microneedling treatment stimulated proliferation and barrier renewal of the skin. The procedure also increased the le

SUBMITTER: Liu X 

PROVIDER: S-EPMC9613915 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature