Gross tumour volume radiomics for prognostication of recurrence & death following radical radiotherapy for NSCLC.

ABSTRACT: Recurrence occurs in up to 36% of patients treated with curative-intent radiotherapy for NSCLC. Identifying patients at higher risk of recurrence for more intensive surveillance may facilitate the earlier introduction of the next line of treatment. We aimed to use radiotherapy planning CT scans to develop radiomic classification models that predict overall survival (OS), recurrence-free survival (RFS) and recurrence two years post-treatment for risk-stratification. A retrospective multi-centre study of >900 patients receiving curative-intent radiotherapy for stage I-III NSCLC was undertaken. Models using radiomic and/or clinical features were developed, compared with 10-fold cross-validation and an external test set, and benchmarked against TNM-stage. Respective validation and test set AUC

SUBMITTER: Hindocha S 

PROVIDER: S-EPMC9613990 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature