A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer.

ABSTRACT: Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features, hormone receptor expression patterns, prognostic factors, and genetic characteristics as their human counterparts. We aimed to develop in vitro tools that allow functional analysis of canine mammary tumors (CMT), as we have a poor understanding of the underlying biology that drives the growth of these heterogeneous tumors. We established the long-term culture of 24 organoid lines from 16 dogs, including organoids derived from normal mammary epithelium or benign lesions. CMT organoids recapitulated key morphological and immunohistological features of the primary tissue from which they were derived, in

SUBMITTER: Inglebert M 

PROVIDER: S-EPMC9614008 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature